BCR-ABL Quantitative (Philadelphia Chromosome) (MB0008)

Description

BCR-ABL Quantitative (Philadelphia Chromosome) is a highly specialized molecular hematology test used to detect and quantify BCR-ABL1 fusion gene transcripts caused by the t(9;22) translocation, also known as the Philadelphia chromosome. This test is primarily used for the diagnosis support, baseline quantification, treatment monitoring, molecular response assessment, and relapse surveillance of Chronic Myeloid Leukemia (CML) and selected cases of Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL). The assay is commonly performed using Quantitative Reverse Transcription PCR (RT-PCR / qRT-PCR) to measure BCR-ABL1 mRNA transcript levels, most commonly the p210 (major breakpoint; e13a2/e14a2) transcript associated with CML, and in some panels also the p190 (minor breakpoint; e1a2) transcript associated more often with Ph+ ALL. For p210 BCR-ABL1, results are often standardized to the International Scale (IS) and reported as % BCR-ABL1/ABL1, enabling long-term treatment monitoring and response comparison across time. This test is essential for evaluating response to tyrosine kinase inhibitor (TKI) therapy such as imatinib, dasatinib, nilotinib, bosutinib, or ponatinib, and helps guide hematology/oncology treatment decisions. Labcorp notes that the assay can detect e13a2 (b2a2), e14a2 (b3a2), and e1a2 (p190) transcripts, and for p210 the numeric result is reported as % BCR-ABL1/ABL1 on the International Scale (IS).

Report Time

Fasting

Not Required

Reporting Time

7–10 Days

Gender

Male/Female

Age Group

5-99 yrs.

Pre-Test Instructions:

No fasting required
Collect in EDTA (lavender top) tube
Do not use clotted sample
Mix gently by inversion after collection
Send whole blood in original tube
Do not aliquot unless referral lab specifically instructs
Preferred specimen is peripheral blood for routine monitoring
Bone marrow may be used in selected hematology cases
Sample should ideally reach testing lab within 48–72 hours
Keep at room temperature if prompt transport; refrigerate if delayed
Do NOT freeze whole blood or bone marrow
Avoid gross hemolysis, leaking tubes, clotted samples, or degraded specimens

Parameters Covered

रु 12,000

✔ Home collection available ✔ No hidden charges

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BCR-ABL Quantitative (Philadelphia Chromosome) (MB0008)

Description

Report Time

Pre-Test Instructions:

Parameters Covered

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